Relieving tension headaches. It may also be used for other conditions as determined by your doctor.

How these medicines work is not completely understood. Acetaminophen works in the brain to relieve pain. Caffeine may work by constricting blood vessels that may cause headaches. Butalbital has a depressant effect that reduces anxiety and causes relaxation.

• you are allergic to any ingredient in Esgic-Plus
• you have the blood disease porphyria
• you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Some medical conditions may interact with Esgic-Plus . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have liver problems, severe kidney problems, severe heart disease, a lung or respiratory tract disease, or difficulty sleeping
• if you have a history of substance abuse or dependence, anxiety, depression, or suicidal thoughts or behaviors

Some MEDICINES MAY INTERACT with Esgic-Plus . Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin) or isoniazid because the risk of side effects, including bleeding and liver problems, may be increased
• Benzodiazepines (eg, chlordiazepoxide), monoamine oxidase (MAO) inhibitors (eg, phenelzine), narcotic analgesics (eg, morphine), sleeping medicines (eg, temazepam), or sodium oxybate (GHB) because they may increase the risk of Esgic-Plus 's side effects
• Beta-blockers (eg, atenolol), clozapine, corticosteroids (eg, prednisone), doxycycline, estrogens (eg, estradiol, oral contraceptives), metronidazole, quinidine, quinolone antibiotics (eg, ciprofloxacin), or theophylline, because their effectiveness may be decreased by Esgic-Plus

This may not be a complete list of all interactions that may occur. Ask your health care provider if Esgic-Plus may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.