Use Esgic-Plus as directed by your doctor. Check the label on the medicine for exact dosing instructions.

• Esgic-Plus may be taken with or without food.
• If you miss a dose of Esgic-Plus and you are taking it regularly, take it as soon as possible. If several hours have passed or if it is almost time for your next dose, do not double the dose to catch up, unless advised to do so by your doctor. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Esgic-Plus .

• Esgic-Plus may cause drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Esgic-Plus . Using Esgic-Plus alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
• Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Esgic-Plus . Esgic-Plus will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
• Do not exceed the recommended dose or take Esgic-Plus for longer than prescribed without checking with your doctor. Exceeding the recommended dose or taking Esgic-Plus for longer than prescribed may be habit-forming.
• Pain medications work best if they are used as the first signs of pain (or migraine) occur. If you wait until the pain has significantly worsened, the pain medicine may not work as well.
• Esgic-Plus contains acetaminophen. Before you begin taking any new prescription or over-the-counter medicine, read the ingredients to see if it also contains acetaminophen. If it does or if you are uncertain, contact your doctor or pharmacist.
• Esgic-Plus may cause liver damage. If you consume 3 or more alcohol-containing drinks every day, ask your doctor whether you should take Esgic-Plus or other pain relievers/fever reducers. Alcohol use combined with Esgic-Plus may increase your risk for liver damage.
• Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Esgic-Plus .
• Esgic-Plus may decrease the effectiveness of your birth control pill. To prevent pregnancy, be sure to use an additional form of birth control (eg, condoms) while using Esgic-Plus .
• Lab tests, including liver and kidney function, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
• Use Esgic-Plus with caution in the ELDERLY because they may be more sensitive to its effects.
• Use Esgic-Plus with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
• PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Esgic-Plus during pregnancy. Esgic-Plus is excreted in breast milk. Do not breast-feed while taking Esgic-Plus .

When used for long periods of time or at high doses, Esgic-Plus may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE. Talk with your doctor if Esgic-Plus stops working well. Do not take more than prescribed.

When used for long periods of time or at high doses, some people develop a need to continue taking Esgic-Plus . This is known as DEPENDENCE or addiction. If you become addicted to Esgic-Plus and you suddenly stop taking it, you may experience WITHDRAWAL symptoms, including anxiety, muscle twitching, trembling hands and fingers, weakness, dizziness, hallucinations, nausea, vomiting, sleeplessness, lightheadedness, or seizures.